ea0029p1149 | Neuroendocrinology | ICEECE2012
Cuesta M.
, Gomez-Hoyos E.
, Montanez C.
, Martin P.
, Marcuello C.
, de Miguel P.
, Calle A.
, Runkle I.
Tolvaptan (TV), an ADH V2-receptor blocker, is useful in treating SIADH-induced hyponatremia. Maximum aquaresis following 15 mg TV occurs on day 1, when excess body water is greatest. This can cause a sharp rise in natremia, and poses a risk of overcorrection. Our aim was to evaluate an initial dose of 7.5 mg.Methods: We studied 7 hospitalized patients with SIADH (4 females), median age 80 (5795), with nadir natremias (Nap) ranging from ...